The angry Raja (Arshad Warsi), schizophrenic Gangadhar (Rajpal Yadav), Dr. Mukherjee (Irrfan Khan) and the cute Dabboo (Suresh Menon) are all unique in their mental imbalance. Dr. Sonali (Juhi Chawla) is treating all four of them. While Raja is diagnosed with intermittent explosive disorder, due to his sudden anger at the slightest provocation, Gangadhar is living in the past where he shares friendship with Jawaharlal Nehru, Mahatma Gandhi, Lokamanya Tilak and Sardar Vallabhai Patel. He seems busy in fighting for the country’s freedom, which was achieved long back. Dr. Mukherjee, who is a perfect doctor and is one keeps himself tidy and prim, is diagnosed with obsessive compulsive personality disorder. Dabboo, who has not spoken for years and appears frightened all the time, appears autistic and is loved by one and all. Shikha (Dia Mirza), a television reporter and who loves Raja, cannot seem to help bring sanity in him. R K Sanyal (Rajat Kapoor), who is an industrialist and the husband of Dr. Sonali, gets vexed up with the four patients and attempts to get rid of them. How this story unfolds forms the climax of the story.